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Retatrutide vs Semaglutide
The honest difference
Semaglutide is a proven, licensed UK medicine. Retatrutide gave bigger weight loss in trials, but is still experimental and unlicensed.
Peptide
Retatrutide
Grade B: promising human evidence
Why people buy it
People buy it to lose weight. It is a new weight-loss injection still being tested by a drug company.
Bottom line
A strong weight-loss drug in real trials, but not approved yet. Online vials are not the drug that was tested.
- UK status
- Retatrutide is an investigational medicine with no MHRA marketing authorisation. It is not available on prescription or legally for sale in the UK.
- Sport / WADA
- Prohibited at all times under S0 (non-approved substances). The WADA 2026 Prohibited List bans any substance not covered by another section that has no current approval by any government health authority for human therapeutic use, explicitly including drugs in clinical development.
Peptide
Semaglutide
Grade A: approved / strong human evidence
Why people buy it
This is the real medicine in Ozempic and Wegovy. People take it to lose weight or to control type 2 diabetes.
Bottom line
A proven medicine that really works. Get it from a doctor or pharmacy, not a website.
- UK status
- A fully licensed UK medicine, prescription-only (POM), regulated by the MHRA. Marketed as Ozempic and Rybelsus (type 2 diabetes) and Wegovy (chronic weight management).
- Sport / WADA
- Not prohibited by WADA; semaglutide and GLP-1 receptor agonists are not on the WADA Prohibited List.
Grades are about evidence in humans, not about whether something is right for you. Nothing here is dosing advice. Talk to a qualified clinician before any health decision.
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