Libido & Hormonal

Gonadorelin is a lab-made copy of the brain's own fertility hormone (GnRH) that tells the pituitary gland to release the hormones driving the testes and ovaries. It only works properly when delivered in tiny, regular pulses, the way the body does it naturally.

Grade A · Approved medicine or robust human trials.

A brain-acting peptide that affects sexual desire through melanocortin receptors. It is the only such drug actually approved (in the US, as Vyleesi) for low sexual desire in premenopausal women.

Grade A · Approved medicine or robust human trials.

Oxytocin is a natural hormone and a genuine, decades-old hospital medicine for childbirth that has been heavily marketed as a "love and bonding" nasal spray, but that bonding use mostly fails to hold up in good trials.

Grade B · Human trials exist but are incomplete.

A short lab-made copy of a brain hormone that controls reproduction. Small human studies hint at effects on sexual arousal, but the data is early and the evidence grade reflects that.

Grade C · Some human data, far from settled.

A Russian "bioregulator" sold for prostate health that is really two different products under one banner — a lab-made four-amino-acid peptide with only cell and animal data, and a cow-prostate extract backed by weak Russian studies.

Grade D · No meaningful human evidence yet.